2 California professors share Nobel Prize in medicine

UCSF scientist wins Nobel Prize with discoveries in how bodies react to heat and cold

A Nobel Prize was awarded to UCSF professor whose discoveries have lead to new insights about the fundamental nature of pain.

STOCKHOLM - Two California scientists won the Nobel Prize in medicine on Monday for their discoveries into how the human body perceives temperature and touch, revelations that could lead to new ways of treating pain or even heart disease.

Americans David Julius and Ardem Patapoutian identified receptors in the skin that respond to heat and pressure. Their work is focused on the field of somatosensation, which explores the ability of specialized organs such as eyes, ears and skin to see, hear and feel.

Julius used a compound from chili peppers that induces a burning sensation to identify a sensor in the skin’s nerve endings that responds to heat. Patapoutian used pressure-sensitive cells to discover a new class of sensors that respond to mechanical stimuli in the skin and internal organs.

The Nobel Prize Twitter account showed Julius, who is a physiologist at UCSF, enjoying a cup of coffee early Monday morning.

The photo was taken by his wife and colleague, Holly Ingram, who described Julius as her "best friend in life."

"And we thought this was a prank call," Ingraham tweeted.

"This really unlocks one of the secrets of nature," said Thomas Perlmann, secretary-general of the Nobel Committee, in announcing the winners. "It’s actually something that is crucial for our survival, so it’s a very important and profound discovery."

Patapoutian, who was born in Lebanon and now works at Scripps Research Institute at La Jolla, California, found separate pressure-sensitive sensors in cells that respond to mechanical stimulation, it said.

Perlmann said he managed to get hold of both of the winners — who shared the prestigious Kavli Award for Neuroscience last year — before Monday’s announcement.

"I (...) only had a few minutes to talk to them, but they were incredibly happy," he said. "And as far as I could tell they were very surprised and a little bit shocked, maybe."

The choice of Julius, 65, and Patapoutian underscored how little scientists knew about how our bodies perceive the external world before their discoveries — and how much there still is to learn, said Oscar Marin, director of the MRC Centre for Neurodevelopmental Disorders at King’s College London.

"While we understood the physiology of the senses, what we didn’t understand was how we sensed differences in temperature or pressure," Marin said. "Knowing how our body senses these changes is fundamental because once we know those molecules, they can be targeted. It’s like finding a lock and now we know the precise keys that will be necessary to unlock it."

Marin said the discoveries opened up "an entire field of pharmacology" and that researchers were already working to develop drugs to target the receptors they identified.

Marin predicted that new treatments for pain would likely come first, but that knowing how the body detects changes in pressure could eventually lead to drugs for heart disease, if scientists can figure out how to alleviate pressure on blood vessels and other organs.

Last year’s prize went to three scientists who discovered the liver-ravaging hepatitis C virus, a breakthrough that led to cures for the deadly disease and tests to keep the scourge from spreading though blood banks.

The prestigious award comes with a gold medal and 10 million Swedish kronor (over $1.14 million). The prize money comes from a bequest left by the prize’s creator, Swedish inventor Alfred Nobel, who died in 1895.

The prize is the first to be awarded this year. The other prizes are for outstanding work in the fields of physics, chemistry, literature, peace and economics.

___

Jordans reported from Berlin. KTVU contributed to this report.